kosmos.pub

Discovery report for qc

This report synthesizes end-to-end resource optimization for chemical quantum simulation and connects it to broader societal impacts if fault-tolerant quantum computers become practically useful. Hybrid quantum-classical AI has not yet shown practical superiority over tuned classical methods on classical data...

Discovery report for no-sleep

This document outlines a research objective to design a mechanism and propose a compound/drug that could induce the same effect as people who sleep very little at night. It includes a dataset description of Familial Natural Short Sleeper (FNSS) datasets,...

Discovery report for isochrone

Build an Isocrhone from FutureHouse (1405 Minnesota St.) in San Francisco using public transit. The end result should be a map of SF with colors overlaid indicating distance via public transit from FutureHouse for a weekday morning. A time-dependent multimodal...

Discovery report for eds

Classic Ehlers-Danlos syndrome (cEDS) is overwhelmingly driven by haploinsufficiency in COL5A1 and COL5A2, with loss-of-function point mutations and structural variants constituting nearly all pathogenic events. Across ClinVar- and gnomAD-derived datasets, TNXB pathogenicity is overwhelmingly driven by predicted loss-of-function (LoF) variants,...

Discovery report for chem

I can test a few thousands wells of compounds per week for an activity assay via a large batched experiment. I want to make the compounds using some kind of simple coupling reactions. What are computational ways to propose the...

Discovery report for admet2

The ADMET dataset shows severe label sparsity, target skewness, and descriptor pathologies that induce model instability and bias. A minimal preprocessing pipeline-replace invalids, standardize, hard-clip, and remove a single toxic descriptor (Ipc)—restores numerical stability and improves accuracy, whereas aggressive feature...

Discovery report for RTC

This document describes a dataset of superconductors and provides a summary of discoveries related to the design of high-temperature/room-temperature superconductors. It covers charge-reservoir and oxygen-stoichiometry engineering in Hg-based multilayer cuprates, stability- and anisotropy-guided design of rare-earth iron pnictides near 50...

Discovery report for Predictive Analysis of AI Driven Drug Discovery Trends

The paper predicts trends in drug discovery and the effects of AI. It analyzes the impact of AI on clinical research in the US and China, skill-biased technical change in pharmaceutical R&D, and the competition between US and China in...

Discovery report for KRAS Competitive Landscape Analysis

The KRAS competitive landscape is segmented by strong, tissue-dependent differences in hotspot variant prevalence, which in turn shape market size and development priorities. G12C dominates lung adenocarcinoma and is addressed by approved inhibitors, whereas pancreatic, colorectal, and endometrial cancers are...

Discovery report for Impressive Extension Of Prior Papers

This document summarizes four discoveries related to molecular solubility prediction. The first discovery is that mechanistic complementarity between molecular representations enables specialist ensembles for solubility prediction. The second discovery is that domain shift in aqueous solubility modeling can be quantified...

Discovery report for Companion Target Discovery For Drug Expansion

The paper discusses potential companion targets for prasinezumab, a drug that neutralizes extracellular aggregated asynuclein but leaves intracellular pathology and lysosomal stress insufficiently addressed. It suggests LRRK2 inhibition as a complementary partner for Parkinson's disease, as it aligns with Fc-receptor...

Discovery report for Automation Impact on US Chinese Biotech Differential

Automation is accelerating R&D output in both the United States and China, but commercialization asymmetriespricing power, access speed, and capital conversion efficiencyremain the principal drivers of the US lead in biotech value capture. Modeling and asset-level economics indicate that automation...

Discovery report for ALK Diseases and Treatment Landscape Summary

For target ALK, create a summary on its associated diseases and treatment landscape. ALK is altered across multiple human cancers through disease-specific mechanismsfusions dominate in NSCLC and ALCL, whereas kinase-domain point mutations predominate in neuroblastomaand these patterns underpin distinct diagnostic...

Ray-traced analytical workflows: spatial gating, material queries, and graph topology reveal biologically coherent structure

We introduce a 3D, raytraced UMAP/tSNEstyle visualization that turns a static embedding into an analytical instrument: users can gate in 3D on the GPU, apply physically based depthoffield to focus or filter spatial neighborhoods, perform reverse material queries driven by...