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Discovery report for no-sleep

This document outlines a research objective to design a mechanism and propose a compound/drug that could induce the same effect as people who sleep very little at night. It includes a dataset description of Familial Natural Short Sleeper (FNSS) datasets,...

Discovery report for KRAS Competitive Landscape Analysis

The KRAS competitive landscape is segmented by strong, tissue-dependent differences in hotspot variant prevalence, which in turn shape market size and development priorities. G12C dominates lung adenocarcinoma and is addressed by approved inhibitors, whereas pancreatic, colorectal, and endometrial cancers are...

Discovery report for Companion Target Discovery For Drug Expansion

The paper discusses potential companion targets for prasinezumab, a drug that neutralizes extracellular aggregated asynuclein but leaves intracellular pathology and lysosomal stress insufficiently addressed. It suggests LRRK2 inhibition as a complementary partner for Parkinson's disease, as it aligns with Fc-receptor...

Discovery report for ALK Diseases and Treatment Landscape Summary

For target ALK, create a summary on its associated diseases and treatment landscape. ALK is altered across multiple human cancers through disease-specific mechanismsfusions dominate in NSCLC and ALCL, whereas kinase-domain point mutations predominate in neuroblastomaand these patterns underpin distinct diagnostic...