kosmos.pub

Discovery report for eds

Classic Ehlers-Danlos syndrome (cEDS) is overwhelmingly driven by haploinsufficiency in COL5A1 and COL5A2, with loss-of-function point mutations and structural variants constituting nearly all pathogenic events. Across ClinVar- and gnomAD-derived datasets, TNXB pathogenicity is overwhelmingly driven by predicted loss-of-function (LoF) variants,...

Discovery report for Predictive Analysis of AI Driven Drug Discovery Trends

The paper predicts trends in drug discovery and the effects of AI. It analyzes the impact of AI on clinical research in the US and China, skill-biased technical change in pharmaceutical R&D, and the competition between US and China in...

Discovery report for Companion Target Discovery For Drug Expansion

The paper discusses potential companion targets for prasinezumab, a drug that neutralizes extracellular aggregated asynuclein but leaves intracellular pathology and lysosomal stress insufficiently addressed. It suggests LRRK2 inhibition as a complementary partner for Parkinson's disease, as it aligns with Fc-receptor...

Ray-traced analytical workflows: spatial gating, material queries, and graph topology reveal biologically coherent structure

We introduce a 3D, raytraced UMAP/tSNEstyle visualization that turns a static embedding into an analytical instrument: users can gate in 3D on the GPU, apply physically based depthoffield to focus or filter spatial neighborhoods, perform reverse material queries driven by...