kosmos.pub

Discovery report for no-sleep

This document outlines a research objective to design a mechanism and propose a compound/drug that could induce the same effect as people who sleep very little at night. It includes a dataset description of Familial Natural Short Sleeper (FNSS) datasets,...

Discovery report for eds

Classic Ehlers-Danlos syndrome (cEDS) is overwhelmingly driven by haploinsufficiency in COL5A1 and COL5A2, with loss-of-function point mutations and structural variants constituting nearly all pathogenic events. Across ClinVar- and gnomAD-derived datasets, TNXB pathogenicity is overwhelmingly driven by predicted loss-of-function (LoF) variants,...

Discovery report for KRAS Competitive Landscape Analysis

The KRAS competitive landscape is segmented by strong, tissue-dependent differences in hotspot variant prevalence, which in turn shape market size and development priorities. G12C dominates lung adenocarcinoma and is addressed by approved inhibitors, whereas pancreatic, colorectal, and endometrial cancers are...

Discovery report for ALK Diseases and Treatment Landscape Summary

For target ALK, create a summary on its associated diseases and treatment landscape. ALK is altered across multiple human cancers through disease-specific mechanismsfusions dominate in NSCLC and ALCL, whereas kinase-domain point mutations predominate in neuroblastomaand these patterns underpin distinct diagnostic...